Premature death from noncommunicable diseases (NCDs) continues to be one of the major development challenges in the 21st century. NCDs kill 15 million women and men between the ages of 30 and 70 each year, and leave no country untouched. This burden is rising disproportionately among low-income and lower-middle-income countries, where almost half of premature NCD deaths occur. Within countries, these deaths disproportionally affect the poorest and those furthest behind. The NCD epidemic is driven by poverty, globalization of marketing and trade of health-harming products, rapid urbanization, and population growth. This Progress Monitor is based on the latest data tracked against 10 progress indicators to chart progress in developing national responses. It describes achievements and challenges faced by all countries in fulfilling promises made since the first United Nations High-level Meeting on NCDs in 2011.